Since their first demonstration of manipulation and mechanical coiling of a single DNA
molecule, magnetic tweezers have become a popular and widely used single-molecule …

The advent of new technologies allowing the study of single biological molecules continues
to have a major impact on studies of interacting systems as well as enzyme reactions. These …

The double-stranded nature of DNA links its replication, transcription and repair to rotational
motion and torsional strain. Magnetic tweezers (MT) are a powerful single-molecule …

During recombinational repair of double-stranded DNA breaks, RAD51 recombinase
assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically …

Single-molecule measurements of DNA twist and extension have been used to reveal
physical properties of the double helix and to characterize structural dynamics and …

The G-rich single-stranded DNA at the 3′ end of human telomeres can self-fold into G-
quaduplex (GQ). However, telomere lengthening by telomerase or the recombination-based …

To understand the mechanistic basis of cellular function, immense efforts are undertaken to
investigate the many different molecules that constitute a cell, aiming to probe both …

Over the past two decades, measurements on individual stretched and twisted DNA
molecules have helped define the basic elastic properties of the double helix and enabled …

Magnetic tweezers are a single-molecule force and torque spectroscopy technique that
enable the mechanical interrogation in vitro of biomolecules, such as nucleic acids and …

We present here the principle of soft magnetic tweezers which improve the traditional
magnetic tweezers allowing the simultaneous application and measurement of an arbitrary …