Osteoarthritis: new insights. Part 1: the disease and its risk factors

DT Felson, RC Lawrence, PA Dieppe… - Annals of internal …, 2000 - acpjournals.org
Osteoarthritis is the most common form of arthritis, affecting millions of people in the United
States. It is a complex disease whose etiology bridges biomechanics and biochemistry …

Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression

G Musumeci, FC Aiello, MA Szychlinska… - International journal of …, 2015 - mdpi.com
Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than
half of the over 65 population. In the past, OA was considered a wear and tear disease …

Republished: Value of biomarkers in osteoarthritis: current status and perspectives

M Lotz, J Martel-Pelletier, C Christiansen… - Postgraduate …, 2014 - academic.oup.com
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci,
ligaments and subchondral bone, and synovial inflammation. Biomarkers are being …

[PDF][PDF] Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

JP Pelletier, J Martel‐Pelletier… - Arthritis & Rheumatism …, 2001 - stem-art.com
Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

[图书][B] The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

J Bondeson, AB Blom, S Wainwright, C Hughes… - 2012 - academia.edu
Osteoarthritis (OA), one of the most common diseases among humans, is characterised
pathologically by focal areas of damage on articular cartilage centred on load-bearing …

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory …

J Bondeson, SD Wainwright, S Lauder, N Amos… - Arthritis research & …, 2006 - Springer
There is an increasing body of evidence that synovitis plays a role in the progression of
osteoarthritis and that overproduction of cytokines and growth factors from the inflamed …

[HTML][HTML] NLRP3 as a potentially novel biomarker for the management of osteoarthritis

MJ McAllister, M Chemaly, AJ Eakin, DS Gibson… - Osteoarthritis and …, 2018 - Elsevier
Osteoarthritis (OA) was previously thought of as 'wear and tear'as humans age, however
there is increasing evidence to support an inflammatory theory. The nucleotide-binding and …

Osteoarthritis: an overview of the disease and its treatment strategies

P Sarzi-Puttini, MA Cimmino, R Scarpa… - Seminars in arthritis and …, 2005 - Elsevier
Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …

[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

[HTML][HTML] Classification of osteoarthritis biomarkers: a proposed approach

DC Bauer, DJ Hunter, SB Abramson, M Attur… - Osteoarthritis and …, 2006 - Elsevier
OBJECTIVE: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to
assist in disease diagnosis and assessment of disease severity, risk of onset, and …