Over the last decade, based on the extensive development of preclinical animal studies and
clinical trials, the efficacy, and mechanisms of immunotherapy have been fully explored …

Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

The idea that tumors must “escape” from immune recognition contains the implicit
assumption that tumors can be destroyed by immune responses either spontaneously or as …

Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it
is clear that tumors express many neoantigens. A central question in cancer immunology is …

Diagnostic records from 338 canine oral melanomas in 338 dogs received at the Veterinary
Medical Diagnostic Laboratory (1992-1999) were reviewed. Of these tumors, 122 plus an …

Tumor cells may express antigens which are recognized in a form of HLA/peptide
complexes by T cells. The frequency at which different antigens are seen by T cells of …

Purpose: Melanoma cells express antigens that can induce T-cell and antibody responses.
Obtaining a detailed understanding of antigen expression in primary and metastatic …

Characterization of cytolytic T lymphocyte (CTL) responses to tumor antigens has been
impeded by a lack of direct assays of CTL activity. We have synthesized reagents …

The goal of tumor immunotherapy is to elicit immune responses against autologous tumors.
It would be highly desirable that such responses include multiple T cell clones against …

Cancer/testis‐associated genes (CTAs) are a subgroup of tumor antigens with a restricted
expression in testis and malignancies. During the last decade, many of these …