Research progress on mechanism of podocyte depletion in diabetic nephropathy

H Dai, Q Liu, B Liu - Journal of diabetes research, 2017 - Wiley Online Library
Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in
the development of diabetic microangiopathy in the initial stage of diabetic diseases …

Acute kidney injury and progression of diabetic kidney disease

SMW Yu, JV Bonventre - Advances in chronic kidney disease, 2018 - Elsevier
Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

The MSC-derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via MicroRNA-152-3p

B Li, S Luan, J Chen, Y Zhou, T Wang, Z Li, Y Fu… - … Therapy-Nucleic Acids, 2020 - cell.com
Mesenchymal stem cells (MSCs) have been reported to hold promise to accelerate the
wound-healing process in diabetic foot ulcer (DFU) due to the multilineage differentiation …

Therapeutic miR-21 silencing ameliorates diabetic kidney disease in mice

M Kölling, T Kaucsar, C Schauerte, A Hübner… - Molecular Therapy, 2017 - cell.com
Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are
powerful regulators of the genome, and global expression profiling revealed miR-21 to be …

Podocytes: the weakest link in diabetic kidney disease?

JS Lin, K Susztak - Current diabetes reports, 2016 - Springer
Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in
the United States. Diabetic kidney disease is considered a proteinuric glomerular disease …

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

H Peng, Q Wang, T Lou, J Qin, S Jung, V Shetty… - Nature …, 2017 - nature.com
Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the
development of chronic kidney disease (CKD). Exercise has been associated with beneficial …

Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of …

X Zhao, Y Chen, X Tan, L Zhang, H Zhang… - The Journal of …, 2018 - Wiley Online Library
Insufficient autophagy in podocytes is related to podocyte injury in diabetic nephropathy
(DN). Advanced glycation end‐products (AGEs) are major factors of podocyte injury in DN …

Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin II‐induced hypertension

C An, B Jiao, H Du, M Tran, D Zhou… - Journal of cellular …, 2022 - Wiley Online Library
Hypertension is a major cause of chronic kidney disease. However, the pathogenesis of
hypertensive kidney disease is not fully understood. Recently, we have shown that CXCL16 …

Proteinuric kidney diseases: a podocyte's slit diaphragm and cytoskeleton approach

SMW Yu, P Nissaisorakarn, I Husain, B Jim - Frontiers in Medicine, 2018 - frontiersin.org
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

NLRP3-mediated pyroptosis in diabetic nephropathy

J Wan, D Liu, S Pan, S Zhou, Z Liu - Frontiers in pharmacology, 2022 - frontiersin.org
Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is
characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss …