Spheroids have emerged as in vitro models that reproduce in a great extent the architectural
microenvironment found in human tissues. However, the imaging of 3D cell cultures is highly …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Three‐dimensional reconstruction of tissue structures is essential for biomedical research.
The development of light microscopes and various fluorescent labeling techniques provides …

Tissue optical clearing enables imaging deeper in large volumes with high-resolution. Clear
T2 is a relatively rapid clearing method with no use of solvents or detergents, hence poses …

This review delves into the rapidly evolving field of deep tissue imaging at cellular
resolution, reviewing popular tissue clearing and staining methods in combination with light …

Understanding how the brain functions is one of the grand challenges in modern scientific
research. Similar to a computer, a functional brain is composed of hardware and software …

We present a method for low-cost fabrication of polydimethylsiloxane (PDMS) tissue
simulating phantoms with tunable scattering spectra, spanning visible, and near-infrared …

Abstract In three‐dimensional (3D) space, an unbiased and systemic view of human
specimens between structures and functions is required. However, conventional histological …

The PeriFlux 6000 EPOS system combines diffuse reflectance spectroscopy (DRS) and
laser Doppler flowmetry (LDF) for the assessment of oxygen saturation (expressed in …

A fiber-optic probe-based instrument, designed for assessment of parameters related to
microcirculation, red blood cell tissue fraction (f RBC), oxygen saturation (SO 2), and speed …