Current knowledge and pharmacological profile of berberine: an update

A Kumar, K Chopra, M Mukherjee… - European journal of …, 2015 - Elsevier
Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous
medicinal plants and has an array of pharmacological properties. It has been used in …

Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF‐κB, JAK/STAT, and MAPK signaling pathways

SM Haftcheshmeh, M Abedi… - Phytotherapy …, 2022 - Wiley Online Library
Three main inflammatory signaling pathways include nuclear factor‐κB (NF‐κB), Janus
kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen …

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease

EJ Seo, N Fischer, T Efferth - Pharmacological research, 2018 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology
of this disease remains incompletely understood and safe and effective therapies are …

Antioxidant and anti‐inflammatory activities of berberine in the treatment of diabetes mellitus

Z Li, YN Geng, JD Jiang… - … Based Complementary and …, 2014 - Wiley Online Library
Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes
mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis …

The pathogenesis of diabetes mellitus by oxidative stress and inflammation: its inhibition by berberine

X Ma, Z Chen, L Wang, G Wang, Z Wang… - Frontiers in …, 2018 - frontiersin.org
A substantial knowledge on the pathogenesis of diabetes mellitus (DM) by oxidative stress
and inflammation is available. Berberine is a biologically active botanical that can combat …

[HTML][HTML] Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

A Chauhan, AU Islam, H Prakash, S Singh - Journal of pharmaceutical …, 2022 - Elsevier
Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for
various biological cell functions. NF-κB consists of five transcription factors that execute both …

Anti-neuroinflammatory potential of natural products in attenuation of Alzheimer's disease

B Shal, W Ding, H Ali, YS Kim, S Khan - Frontiers in pharmacology, 2018 - frontiersin.org
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder associated
with dementia and cognitive impairment most common in elderly population. Various …

Berberine: a review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases

X Ai, P Yu, L Peng, L Luo, J Liu, S Li, X Lai… - Frontiers in …, 2021 - frontiersin.org
Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

Plant alkaloids as drug leads for Alzheimer's disease

YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …

Neuroprotective properties of berberine: Molecular mechanisms and clinical implications

E Tian, G Sharma, C Dai - Antioxidants, 2023 - mdpi.com
Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …