RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …

Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder
caused by expansion of 55–200 CGG repeats in the 5′‐UTR of the FMR1 gene. FXTAS is …

The assembly of synapses and neuronal circuits relies on an array of molecular recognition
events and their modification by neuronal activity. Neurexins are a highly polymorphic family …

The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many
important neuronal transcripts and have been implicated in a variety of neurological …

Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer …

Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of
generating mature spermatozoa. The developmental processes acting on male germ cells …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by loss of motor
neurons in patients with null mutations in the SMN1 gene. An almost identical SMN2 gene is …

Pre-mRNA processing, including 5′-end capping, splicing, editing, and polyadenylation,
consists of a series of orchestrated and primarily cotranscriptional steps that ensure both the …