Effects of replacing oxygenated functionality with fluorine on lipophilicity
RJ Glyn, G Pattison - Journal of Medicinal Chemistry, 2021 - ACS Publications
The replacement of oxygenated functionality (hydroxy and alkoxy) with a fluorine atom is a
commonly used bioisosteric replacement in medicinal chemistry. In this paper, we use …
commonly used bioisosteric replacement in medicinal chemistry. In this paper, we use …
The effects on lipophilicity of replacing oxygenated functionality with their fluorinated bioisosteres
RJ Glyn, G Pattison - 2021 - chemrxiv.org
The replacement of oxygenated functionality (hydroxy, alkoxy) with a fluorine atom is a very
commonly used bioisosteric replacement in medicinal chemistry. In this paper we use a …
commonly used bioisosteric replacement in medicinal chemistry. In this paper we use a …