The past two decades have witnessed remarkable advances in oxidative stress research,
particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues …

Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Stroke is a serious neurological disease, and constitutes a major cause of death and
disability throughout the world. The pathophysiology of stroke is complex, and involves …

Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion.
Occludin and claudins are recently described tight junction proteins (TJPs) that form the …

Deleterious processes of extracellular proteolysis may contribute to the progression of tissue
damage after acute brain injury. We recently showed that matrix metalloproteinase-9 (MMP …

Background and Purpose—Reperfusion disrupts cerebral capillaries, causing cerebral
edema and hemorrhage. Middle cerebral artery occlusion (MCAO) induces the matrix …

Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous
system. Here we review the evidence that supports this idea and discuss the possible …