1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Inflammation is thought to play an important role in the pathogenesis of vascular diseases.
Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies
directed against IgE can alleviate hay fever and allergic asthma,. Genetic association …

The development of atherosclerotic vascular disease is invariably linked to the formation of
bioactive lipid mediators and accompanying vascular inflammation. Lipoprotein-associated …

Background—Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as
an inflammatory marker of cardiovascular disease. In the present study, we investigated …

Phospholipases A2 (PLA2s) belong to a superfamily of enzymes that catalyze the hydrolysis
of glycerophospholipids at the sn-2 position, producing nonesterified fatty acids, such as …

Introduction This article is focused on platelet-activating factor acetylhydrolase (PAF-AH), a
lipoprotein bound, calcium-independent phospholipase A 2 activity also referred to as …

Lipoprotein-associated phospholipase A 2 (Lp-PLA 2), also known as platelet-activating
factor acetylhydrolase (PAF-AH), is a unique member of the phospholipase A 2 superfamily …

Platelet-activating factor (PAF) is a potent proinflammatory phospholipid with diverse
pathological and physiological effects. This bioactive phospholipid mediates processes as …