Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
RB Kang, Y Li, C Rosselot, T Zhang, M Siddiq… - Genome Medicine, 2023 - Springer
Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into
human islet cell types and their corresponding stable gene expression profiles. However …
human islet cell types and their corresponding stable gene expression profiles. However …
Cell heterogeneity and paracrine interactions in human islet function: a perspective focused in β-cell regeneration strategies
E Bru-Tari, D Oropeza, PL Herrera - Frontiers in endocrinology, 2021 - frontiersin.org
The β-cell regeneration field has shown a strong knowledge boost in the last 10 years.
Pluripotent stem cell differentiation and direct reprogramming from other adult cell types are …
Pluripotent stem cell differentiation and direct reprogramming from other adult cell types are …
Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors
VA Cochrane, Y Wu, Z Yang, A ElSheikh… - Journal of Biological …, 2020 - ASBMB
The adipocyte-derived hormone leptin increases trafficking of K ATP and Kv2. 1 channels to
the pancreatic β-cell surface, resulting in membrane hyperpolarization and suppression of …
the pancreatic β-cell surface, resulting in membrane hyperpolarization and suppression of …
Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different …
RB Kang, Y Li, C Rosselot, T Zhang, M Siddiq… - bioRxiv, 2022 - biorxiv.org
Single-cell RNA sequencing (scRNA-seq) has provided valuable insights into human islet
cell types and their corresponding stable gene expression profiles. However, this approach …
cell types and their corresponding stable gene expression profiles. However, this approach …
[HTML][HTML] Retrieval and purification of human β cells from stem cell-derived islet engrafted mice
JHR Kenty, GC Pelayo, NC Leite - STAR protocols, 2021 - Elsevier
Stem cell-derived beta cells (SC-β-cells) engrafted into mice serve as a pre-clinical model of
diabetes. It is helpful to recover viable β cells following transplantation to perform tests on …
diabetes. It is helpful to recover viable β cells following transplantation to perform tests on …
[引用][C] Leptin signaling in pancreatic β-cells: a mechanism to regulate KATP channel trafficking and β-cell electrical activity
V Cochrane - 2021 - Oregon Health & Science University
[引用][C] https://www. jbc. org/cgi/doi/10.1074/jbc. RA120. 015489 The latest version is at
VA Cochrane, Y Wu, Z Yang, A ElSheikh, J Dunford…