Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority of
malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …

A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …

Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …