Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

Aims Coronary vasculature formation is a critical event during cardiac development,
essential for heart function throughout perinatal and adult life. However, current …

Endothelial cells (ECs) sense and respond to fluid flow and regulate immune cell trafficking
in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous …

Endothelium has a rich vesicular network that allows the exchange of macromolecules
between blood and parenchymal cells. This feature of endothelial cells, along with their …

BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined
by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta
(TGFβ) superfamily of cytokines. While some ligand members are potent inducers of …

The formation of new blood vessels after myocardial infarction (MI) is essential for the
survival of existing and regenerated cardiac tissue. However, the extent of endogenous …

Cell segregation allows the compartmentalization of cells with similar fates during
morphogenesis, which can be enhanced by cell fate plasticity in response to local molecular …