Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology

CG Ethun, MA Bilen, AB Jani, SK Maithel… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE The concept of frailty has become increasingly
recognized as one of the most important issues in health care and health outcomes and is of …

Ixazomib for the treatment of multiple myeloma

PG Richardson, S Zweegman… - Expert opinion on …, 2018 - Taylor & Francis
ABSTRACT Introduction: Proteasome inhibitors (PIs) are among the backbones of multiple
myeloma (MM) treatment; however, their long-term use can be limited by parenteral …

[HTML][HTML] Daratumumab-based regimens are highly effective and well tolerated in relapsed or refractory multiple myeloma regardless of patient age: subgroup analysis …

MV Mateos, A Spencer, AK Nooka, L Pour… - …, 2020 - ncbi.nlm.nih.gov
The phase 3 POLLUX and CASTOR studies demonstrated superior benefit of daratumumab
plus lenalidomide/dexamethasone or bortezomib/dexamethasone in relapsed/refractory …

[HTML][HTML] Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis

F Schjesvold, PG Richardson, T Facon, A Alegre… - …, 2021 - ncbi.nlm.nih.gov
Multiple myeloma (MM) typically affects elderly patients, with a median age at diagnosis of
69 years. 1 Treatment of elderly patients is challenging due to frailty, comorbidities, and …

[HTML][HTML] How I treat multiple myeloma in geriatric patients

T Facon, X Leleu, S Manier - Blood, 2024 - Elsevier
Multiple myeloma (MM) is primarily a disease of elderly patients. Geriatric aspects in the
context of MM have been poorly investigated until recently. Treatment outcomes for geriatric …

Approaches and challenges in the management of multiple myeloma in the very old: future treatment prospects

NM Kaweme, GJ Changwe, F Zhou - Frontiers in Medicine, 2021 - frontiersin.org
The increasing incidence of geriatric patients with multiple myeloma has elevated concerns
in clinical practice. While the introduction of novel therapeutic agents has substantially …

MiRNA as a Potential Target for Multiple Myeloma Therapy–Current Knowledge and Perspectives

A Szudy-Szczyrek, S Ahern, J Krawczyk… - Journal of Personalized …, 2022 - mdpi.com
Multiple myeloma (MM) is the second most common hematological malignancy. Despite the
huge therapeutic progress thanks to the introduction of novel therapies, MM remains an …

[HTML][HTML] Incidence of skeletal-related events among multiple myeloma patients in the United States at oncology clinics: observations from real-world data

C Kim, S Bhatta, L Cyprien, R Fonseca… - Journal of bone …, 2019 - Elsevier
Skeletal-related events (SREs) are common bone complications in multiple myeloma (MM).
However, there are few real-world reports of their incidence. In this study, a database of …

Clinical outcomes and serum B-cell maturation antigen levels in a real-world unselected population of newly diagnosed multiple myeloma patients

S Jew, S Bujarski, B Regidor, M Emamy-Sadr, R Swift… - Targeted Oncology, 2023 - Springer
Background Progression-free survival (PFS) and overall survival (OS) of newly diagnosed
multiple myeloma (MM) patients have been widely published in the clinical trials setting, but …

Pomalidomide, bortezomib, and dexamethasone at first relapse in lenalidomide‐pretreated myeloma: a subanalysis of OPTIMISMM by clinical characteristics

PG Richardson, F Schjesvold, K Weisel… - European journal of …, 2022 - Wiley Online Library
Objective We evaluated the efficacy and safety of pomalidomide, bortezomib, and
dexamethasone (PVd) vs bortezomib and dexamethasone (Vd) by age, renal function, and …