Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …

Only a limited number of animal species lend themselves to becoming model organisms in
multiple biological disciplines: one of these is the great pond snail, Lymnaea stagnalis …

Although species-specific differences in ion channel properties are well-documented, little
has been known about the properties of the human Nav1. 8 channel, an important …

The link between sodium channel Nav1. 7 and pain has been strengthened by identification
of gain-of-function mutations in patients with inherited erythromelalgia (IEM), a genetic …

We show here that hyperpolarization‐activated current (Ih) unexpectedly acts to inhibit the
activity of dorsal root ganglion (DRG) neurons expressing WT Nav1. 7, the largest inward …

Background Rewarding stimuli in associative learning can transform the irregularly and
infrequently generated motor patterns underlying motivated behaviors into output for …

Hybrid circuits built by creating mono-or bi-directional interactions among living cells and
model neurons and synapses are an effective way to study neuron, synaptic and neural …

Introduction Mathematicians and physicists often generate models of complex networks
starting with first principles. However, for complex biological systems found in neuroscience …

The Nav1. 7 sodium channel is preferentially expressed within dorsal root ganglion (DRG)
and sympathetic ganglion neurons. Gain-of-function mutations that cause the painful …

Most of the software platforms for cellular electrophysiology are limited in terms of flexibility,
hardware support, ease of use, or re-configuration and adaptation for non-expert users …