Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied
on approaches using rodent in vivo models and in vitro cell models including primary …

Abstract Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation
of in vivo cell-cell and cell-extracellular matrix interactions than conventional two …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory
neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu …

Understanding how Aβ42 oligomers induce changes in neurons from a mechanobiological
perspective has important implications in neuronal dysfunction relevant to …

Neurotoxicology is the study of adverse effects on the structure or function of the developing
or mature adult nervous system following exposure to chemical, biological, or physical …

The genotoxicity, development toxicity, carcinogenicity, and acute or chronic toxic effects of
glutaraldehyde (GA), particularly during occupational exposure through its use as a fixative …

Many neurotoxicants affect energy metabolism in man, but currently available test methods
may still fail to predict mito-and neurotoxicity. We addressed this issue using LUHMES cells …

Developmentally neurotoxic chemicals are a diverse set of substances that have the
potential to interfere with the normal development of the nervous system, which, if perturbed …

Harmful algal blooms that can produce toxins are common in the Indian River Lagoon (IRL),
which covers~ 250 km of Florida's east coast. The current study assessed the dynamics of …