Centuries of genome instability and evolution in soft-shell clam, Myaarenaria, bivalve transmissible neoplasia

SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …

Photosymbiosis shaped animal genome architecture and gene evolution as revealed in giant clams

R Li, C Leiva, S Lemer, L Kirkendale, J Li - Communications Biology, 2025 - nature.com
Symbioses are major drivers of organismal diversification and phenotypic innovation.
However, how long-term symbioses shape whole genome evolution in metazoans is still …

A common garden experiment supports a genetic component underlying the increased resilience of common cockle (Cerastoderma edule) to the parasite Marteilia …

A Villalba, RM Coimbra, M Pampín… - Evolutionary …, 2023 - Wiley Online Library
The common cockle is a valuable bivalve species inhabiting the Atlantic European coasts.
The parasite Marteilia cochillia has devastated cockle beds in the southern Galician (NW …

Transmissible cancers, the genomes that do not melt down

G Bramwell, J DeGregori, F Thomas, B Ujvari - Evolution, 2024 - academic.oup.com
Evolutionary theory predicts that accumulation of deleterious mutations in asexually
reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, ie …

Unravelling epigenetic mechanisms in Cerastoderma edule genome: a comparison of healthy and neoplastic cockles

A Viña-Feás, J Temes-Rodríguez… - Molecular Genetics and …, 2024 - Springer
Cancer is a multifaceted genetic disease characterized by the acquisition of several
essential hallmarks. Notably, certain cancers exhibit horizontal transmissibility, observed …

Multiple lineages of transmissible neoplasia in the basket cockle (C. nuttallii) with repeated horizontal transfer of mitochondrial DNA

MA Yonemitsu, JK Sevigny, LE Vandepas, JL Dimond… - bioRxiv, 2023 - biorxiv.org
Transmissible cancers are clonal lineages of neoplastic cells able to infect multiple hosts,
spreading through populations in the environment as an infectious disease. Transmissible …

[HTML][HTML] Novel PCR assay for the identification of two transmissible cancers in Cerastoderma edule

M Santamarina, AL Bruzos, A Pequeño-Valtierra… - Journal of Invertebrate …, 2024 - Elsevier
Transmissible cancers are a rare phenomenon in which cancer cells are passed between
individuals, leading to the development of neoplasia in the host organism. Transmissible …

Horizontal transfer of nuclear DNA in transmissible cancer

KC Gori, A Baez-Ortega, A Strakova, MR Stammnitz… - bioRxiv, 2024 - biorxiv.org
Although somatic cell genomes are usually entirely clonally inherited, nuclear DNA
exchange between cells of an organism can occur sporadically by cell fusion, phagocytosis …

[HTML][HTML] Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer

SFM Hart, FES Garrett, JS Kerr, MJ Metzger - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Transmissible cancers are unique instances in which cancer cells escape their original host
and spread through a population as a clonal lineage, documented in Tasmanian Devils …

Long-read sequencing reveals extensive size variation and suggests evolutionary patterns of expansion in bivalve mitogenomes

N Zhang, L Qi, B Xu, L Kong, Q Li - bioRxiv, 2024 - biorxiv.org
Bilaterian mitochondrial genomes are generally of conserved size and gene content,
typically ranging from 14 to 20 kb and coding 37 genes. However, the major exception to this …