Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Macrophages in vascular inflammation and atherosclerosis

C Cochain, A Zernecke - Pflügers Archiv-European Journal of Physiology, 2017 - Springer
Atherosclerosis is characterized by lipid accumulation and chronic inflammation of the
arterial wall, and its main complications—myocardial infarction and ischemic stroke …

Immune modulation by human secreted RNases at the extracellular space

L Lu, J Li, M Moussaoui, E Boix - Frontiers in immunology, 2018 - frontiersin.org
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …

Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease

L Wang, C Shen, Y Wang, T Zou, H Zhu, X Lu, L Li… - Atherosclerosis, 2019 - Elsevier
Background and aims The role of circular RNAs (circRNAs) in coronary artery disease
(CAD) remains elusive. The aim of the present study was to profile circRNAs expression in …

Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure

A Maciejak, M Kiliszek, M Michalak, D Tulacz… - Genome medicine, 2015 - Springer
Background Heart failure (HF) is the most common cause of morbidity and mortality in
developed countries. Here, we identify biologically relevant transcripts that are significantly …

Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

P Celec, B Vlková, L Lauková, J Bábíčková… - Expert reviews in …, 2018 - cambridge.org
Cell-free DNA (cfDNA) is present in various body fluids and originates mostly from blood
cells. In specific conditions, circulating cfDNA might be derived from tumours, donor organs …

Role of macrophages in cardioprotection

J Yap, HA Cabrera-Fuentes, J Irei… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …

Factor XII: a novel target for safe prevention of thrombosis and inflammation

E Kenne, KF Nickel, AT Long, TA Fuchs… - Journal of internal …, 2015 - Wiley Online Library
Plasma protein factor XII (FXII) activates the procoagulant and proinflammatory contact
system that drives both the kallikrein–kinin system and the intrinsic pathway of coagulation …

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

HA Cabrera-Fuentes, M Ruiz-Meana… - Thrombosis and …, 2014 - thieme-connect.com
Despite optimal therapy, the morbidity and mortality of patients presenting with an acute
myocardial infarction (MI) remain significant, and the initial mechanistic trigger of myocardial …