Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury
M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
Diagnosis and management of neuropathic pain in spine diseases
J Bielewicz, M Kamieniak, M Szymoniuk, J Litak… - Journal of Clinical …, 2023 - mdpi.com
Neuropathic pain is generally defined as a non-physiological pain experience caused by
damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus …
damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus …
Anti-inflammatory-antioxidant modifications and synbiotics improved health-related conditions in patients with progressive forms of multiple sclerosis: A single-center …
AR Moravejolahkami, A Chitsaz… - … Therapies in Clinical …, 2023 - Elsevier
Background and purpose There is growing evidence that dietary modification can improve
clinical manifestations in multiple sclerosis (MS) patients. This study aimed to assess the …
clinical manifestations in multiple sclerosis (MS) patients. This study aimed to assess the …
[HTML][HTML] High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression
Abstract Introduction Selenium (Se) is an essential trace element that exerts its effects
mainly as the proteinogenic amino acid selenocysteine within a small set of selenoproteins …
mainly as the proteinogenic amino acid selenocysteine within a small set of selenoproteins …
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System
MD Kornberg, PA Calabresi - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Acquired demyelinating diseases of the central nervous system (CNS) comprise
inflammatory conditions, including multiple sclerosis (MS) and related diseases, as well as …
inflammatory conditions, including multiple sclerosis (MS) and related diseases, as well as …
Treatment with MDL 72527 ameliorated clinical symptoms, retinal ganglion cell loss, optic nerve inflammation, and improved visual acuity in an experimental model of …
Multiple Sclerosis (MS) is a highly disabling neurological disease characterized by
inflammation, neuronal damage, and demyelination. Vision impairment is one of the major …
inflammation, neuronal damage, and demyelination. Vision impairment is one of the major …
Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China
J Guo, J Wu, L Wang, H Liu, X Wu… - Therapeutic …, 2024 - journals.sagepub.com
Multiple sclerosis (MS) was defined as a rare disease in China due to its low prevalence. For
a long time, interferon β was the only approved disease-modifying therapy (DMT). Since the …
a long time, interferon β was the only approved disease-modifying therapy (DMT). Since the …
Anti-inflammatory action of new hybrid N-acyl-[1,2]dithiolo-[3,4-c]quinoline-1-thione
SM Medvedeva, A Petrou, M Fesatidou… - SAR and QSAR in …, 2024 - Taylor & Francis
Most of pharmaceutical agents display a number of biological activities. It is obvious that
testing even one compound for thousands of biological activities is not practically possible. A …
testing even one compound for thousands of biological activities is not practically possible. A …
Bruton's Tyrosine Kinase Inhibitors for Multiple Sclerosis Treatment: A New Frontier
BM Greenberg - Neurologic Clinics, 2024 - neurologic.theclinics.com
Multiple sclerosis (MS) has had a revolution in therapeutics during the last 30 years. Since
the Federal Drug Administration (FDA) approval of interferon beta 1b in 1993, more than 20 …
the Federal Drug Administration (FDA) approval of interferon beta 1b in 1993, more than 20 …
A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4
Z Song, J Li, Y He, X Wang, J Tian, Y Wu - International …, 2024 - Elsevier
Neuroinflammation and neurodegeneration are hallmarks of multiple sclerosis (MS).
Bromodomain-containing protein 4 (BRD4), a bromodomain and extra-terminal domain …
Bromodomain-containing protein 4 (BRD4), a bromodomain and extra-terminal domain …