Immune responses to stroke: mechanisms, modulation, and therapeutic potential
C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …
development, acute damage cascades, and chronic course after ischemic stroke …
Microglia-mediated neuroinflammation in neurodegenerative diseases
Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …
role in maintaining tissue homeostasis and contributes towards brain development under …
[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
Infection as a stroke risk factor and determinant of outcome after stroke
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …
Pathogenic mechanisms following ischemic stroke
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
The biphasic function of microglia in ischemic stroke
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …
yolk sac. Microglia can be activated within hours and recruited to the lesion site …
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
X Cao - Nature Reviews Immunology, 2016 - nature.com
In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …
receptors (PRRs) have an essential role in recognizing specific components of …
The role of toll‐like receptor 4 in infectious and noninfectious inflammation
M Molteni, S Gemma, C Rossetti - Mediators of inflammation, 2016 - Wiley Online Library
Toll‐like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
They are highly conserved receptors that recognize conserved pathogen‐associated …
They are highly conserved receptors that recognize conserved pathogen‐associated …
Meisoindigo protects against focal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage …
Y Ye, T Jin, X Zhang, Z Zeng, B Ye, J Wang… - Frontiers in cellular …, 2019 - frontiersin.org
Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …