Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

The polycomb group (PcG) proteins are a subset of transcription regulators highly conserved
throughout evolution. Their principal role is to epigenetically modify chromatin landscapes …

Rationale: Glioblastoma (GBM) is the most common and malignant primary brain tumor in
adults. Radiotherapy has long been an important treatment for GBM. Despite recent …

Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and
induces many characteristics of cancer. Hypoxia is associated with metastases and strong …

Prostate cancer (PCa) is one of the most lethal causes of cancer-related death in male. It is
characterized by chromosomal instability and disturbed signaling transduction. E3 ubiquitin …

Aims Psoriasis is a chronic inflammatory skin disease and lysophosphatidic acid (LPA) has
recently been reported to contribute to its pathogenesis through keratinocyte proliferation. In …

Androgen deprivation therapy (ADT) is a cornerstone of prostate cancer (PCa) management.
Although tumors initially regress, many progress to a hormone‐independent state termed …

Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important
transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates …

Emergence of small cell prostate cancer is linked to the plasticity of tumour cells and
avoidance of environmental pressures. This process is thought to be reversable, however to …