Hydrogel‐Embedded Precision‐Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo

R Blomberg, K Sompel, C Hauer… - Advanced …, 2024 - Wiley Online Library
Lung cancer is the leading global cause of cancer‐related deaths. Although smoking
cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have …

Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: the Replica Project

M Caruso, R Emma, A Distefano, S Rust, K Poulas… - Scientific Reports, 2021 - nature.com
Electronic nicotine delivery systems (ENDS) may reduce health risks associated with chronic
exposure to smoke and their potential benefits have been the matter of intense scientific …

Evaluation of Cytotoxicity and Oxidative Stress of Whole Aerosol from Vuse Alto ENDS Products

BM Keyser, R Leverette, J Wertman, T Shutsky… - Toxics, 2024 - mdpi.com
Assessment of in vitro cytotoxicity is an important component of tobacco product
toxicological evaluations. However, current methods of regulatory testing involve exposing …

Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress

C Esquer, O Echeagaray, F Firouzi… - Life Science …, 2022 - life-science-alliance.org
Vaping of flavored liquids has been touted as safe alternative to traditional cigarette smoking
with decreased health risks. The popularity of vaping has dramatically increased over the …

Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency

MC Tsai, RE Rayner, L Chafin… - … of Physiology-Lung …, 2023 - journals.physiology.org
Respiratory viruses, such as influenza, decrease airway cilia function and expression, which
leads to reduced mucociliary clearance and inhibited overall immune defense …

[HTML][HTML] In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products

BM Keyser, R Leverette, R McRae, J Wertman… - Toxicology, 2024 - Elsevier
Heated tobacco products (HTPs) are non-combustible, inhaled tobacco products that
generate an aerosol with fewer and lower levels of toxicants, with a potential to reduce risk …

Transcriptomic Response of Primary Human Bronchial Cells to Repeated Exposures of Cigarette and ENDS Preparations

RE Rayner, J Wellmerling, P Makena, J Zhao… - Cell Biochemistry and …, 2022 - Springer
Cigarette smoke deregulates several biological pathways by modulating gene expression in
airway epithelial cells and altering the physiology of the airway epithelium. The effects of …

Tissue-engineered models of lung cancer premalignancy

R Blomberg, K Sompel, C Hauer, B Peña, J Driscoll… - bioRxiv, 2023 - biorxiv.org
Lung cancer is the leading global cause of cancer-related deaths. Although smoking
cessation is the best preventive action, nearly 50% of all lung cancer diagnoses occur in …

[HTML][HTML] Targeting Airway Immunity in Lung Disease: Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency

MC Tsai, RE Rayner, L Chafin, D Farkas… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Respiratory viruses, such as influenza, decrease airway cilia function and expression, which
leads to reduced mucociliary clearance and inhibited overall immune defense …

Transcriptional Profiling of Memory in Cardiac Interstitial Cells and Pulmonary Response to Vaping

OE Hernandez Echeagaray - 2022 - escholarship.org
Information technology continues to shape and transform biological research. Bioinformatic
research and methods are as diverse and divergent as the biological issues aimed to …