Extramedullary hematopoiesis (EMH) is the formation and development of blood cells
outside the medullary spaces of the bone marrow. Although widely considered an …

The spleen is the major accumulation of lymphoid tissue in the human body, an organ which
prenatally produces and postnatally controls blood cells. Normally, a developed spleen lies …

The autosomal recessive neuromuscular disease spinal muscular atrophy (SMA) is caused
by loss of survival motor neuron (SMN) protein. Molecular pathways that are disrupted …

Enucleation is the hallmark of erythropoiesis in mammals. Previously, we determined that
yolk sac–derived primitive erythroblasts mature in the bloodstream and enucleate between …

Neutrophil retention in and release from the bone marrow is a critical process that remains
incompletely understood. Previous work has implicated the CXCR4/stromal derived factor-1 …

The fetal/neonatal hematopoietic system must generate enough blood cells to meet the
demands of rapid growth. This unique challenge might underlie the high incidence of …

Erythropoietin (Epo) is essential for the terminal proliferation and differentiation of erythroid
progenitor cells. Fibronectin is an important part of the erythroid niche, but its precise role in …

A unique feature in mammalian erythropoiesis is the dramatic chromatin condensation
followed by enucleation. This step-by-step process starts at the beginning of terminal …

Inflammatory cell recruitment requires the concerted action of at least five major sets of
adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate …

Fetal liver (FL) has been described as a source of both hematopoietic and nonhematopoietic
stem cells. Recently we have purified from murine adult bone marrow (BM) a population of …