An overview on the antimalarial activity of 1, 2, 4‐trioxanes, 1, 2, 4‐trioxolanes and 1, 2, 4, 5‐tetraoxanes

M Shukla, K Rathi, M Hassam… - Medicinal Research …, 2024 - Wiley Online Library
The demand for novel, fast‐acting, and effective antimalarial medications is increasing
exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading …

Endoperoxidases in biosynthesis of endoperoxide bonds

S Zhang, B He, A Qu-Bie, M Li, M Luo, M Feng… - International Journal of …, 2024 - Elsevier
Endoperoxides are important sources of ideas for drug discovery. Endoperoxide bonds are
considered to be the cause of the interesting biological activities of endoperoxides, but there …

QSAR, molecular docking and ADMET studies of quinoline, isoquinoline and quinazoline derivatives against Plasmodium falciparum malaria

S El Rhabori, A El Aissouq, S Chtita, F Khalil - Structural Chemistry, 2023 - Springer
With the aim of researching new antimalarial drugs, a series of quinoline, isoquinoline, and
quinazoline derivatives were studied against the Plasmodium falciparum CQ-sensitive and …

Structure-based drug design-guided identification of estrogen receptor binders

R Samanta, KK Pradhan, D Sen, S Kar, M Ghosh - Molecular diversity, 2024 - Springer
Cancer is one of the life-threatening diseases and the second leading cause of death in the
world. The estrogen receptor can be considered as one of the significant drug targets for …

Diversified Synthesis of N-Benzoyl Piperidine Tetraoxane Analogues Using Molybdenum Trioxide as a Newer Catalyst and Its Antiplasmodial Activity

A Kumar, D Agarwal, B Sharma, RD Gupta… - ACS …, 2024 - ACS Publications
Molybdenum trioxide has been proven to be an efficient catalyst in synthesizing mixed N-
benzoyl piperidine dispiro-1, 2, 4, 5-tetraoxane analogues using a one-pot reaction. This …

Recent advances in the synthesis and antimalarial activity of 1, 2, 4-trioxanes

K Rathi, M Shukla, M Hassam, R Shrivastava… - Bioorganic …, 2024 - Elsevier
The increasing resistance of various malarial parasite strains to drugs has made the
production of a new, rapid-acting, and efficient antimalarial drug more necessary, as the …

Novel amino-and hydroxy-functionalized 1, 2, 4-trioxanes and their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via …

P Yadav, NK Naikade, M Hassam, AS Singh… - Bioorganic & Medicinal …, 2024 - Elsevier
Following the economic and social state of humanity, Malaria is categorized as one of the
life-threatening illness epidemics in under developed countries. For the eradication of the …

Novel saturated 1, 2, 4-trioxanes and their antimalarial activity against multidrug resistant Plasmodium yoelii nigeriensis in Swiss mice model via oral route

A Kumari, P Yadav, V Rawat, RA Maurya… - Bioorganic & Medicinal …, 2024 - Elsevier
Abstract Novel saturated 6-(4′-aryloxy phenyl) vinyl 1, 2, 4-trioxanes 12a (1–3)–12d (1–3)
and 13a (1–3)–13d (1–3) have been designed and synthesized, in one single step from …