Micro-ultrasound for preclinical imaging
Over the past decade, non-invasive preclinical imaging has emerged as an important tool to
facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the …
facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the …
Advances in mouse models of prostate cancer
I Ahmad, OJ Sansom, HY Leung - Expert reviews in molecular …, 2008 - cambridge.org
Advances in science and technology have allowed us to manipulate the mouse genome and
analyse the effect of specific genetic alterations on the development of prostate cancer in …
analyse the effect of specific genetic alterations on the development of prostate cancer in …
TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis
Objectives and design We identified a novel TRIM59 gene, as an early signal transducer in
two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We …
two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We …
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue …
Y Lin, G Liu, Y Zhang, YP Hu, K Yu, C Lin, K McKeehan… - 2007 - journals.biologists.com
The fibroblast growth factor (FGF) family consists of 22 members and regulates a broad
spectrum of biological activities by activating diverse isotypes of FGF receptor tyrosine …
spectrum of biological activities by activating diverse isotypes of FGF receptor tyrosine …
Preclinical imaging of prostate cancer
C Olkowski, B Fernandes, GL Griffiths, F Lin… - Seminars in Nuclear …, 2023 - Elsevier
Prostate cancer remains a major cause of mortality and morbidity, affecting millions of men,
with a large percentage expected to develop the disease as they reach advanced ages …
with a large percentage expected to develop the disease as they reach advanced ages …
Innovative biomarkers for prostate cancer early diagnosis and progression
The marker currently used for prostate cancer (CaP) detection is an increase in serum
prostate-specific antigen (PSA). However, the PSA test which may give false positive or …
prostate-specific antigen (PSA). However, the PSA test which may give false positive or …
Harnessing preclinical mouse models to inform human clinical cancer trials
DH Gutmann, K Hunter-Schaedle… - The Journal of clinical …, 2006 - Am Soc Clin Investig
The urgent need for better cancer treatments has stimulated interest in employing small-
animal models to evaluate potential drug therapies. Robust mouse models of many human …
animal models to evaluate potential drug therapies. Robust mouse models of many human …
Characterization of the Oncogenic Activity of the Novel TRIM59 Gene in Mouse Cancer Models
F Valiyeva, F Jiang, A Elmaadawi, M Moussa… - Molecular cancer …, 2011 - AACR
A novel TRIM family member, TRIM 59 gene was characterized to be upregulated in SV40
Tag oncogene–directed transgenic and knockout mouse prostate cancer models as a …
Tag oncogene–directed transgenic and knockout mouse prostate cancer models as a …
Modeling prostate cancer: a perspective on transgenic mouse models
V Jeet, PJ Russell, A Khatri - Cancer and Metastasis Reviews, 2010 - Springer
Despite considerable success in treatment of early stage localized prostate cancer (PC),
acute inadequacy of late stage PC treatment and its inherent heterogeneity poses a …
acute inadequacy of late stage PC treatment and its inherent heterogeneity poses a …
Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound
Background Genetically engineered mouse models are essential to the investigation of the
molecular mechanisms underlying human prostate pathology and the effects of therapy on …
molecular mechanisms underlying human prostate pathology and the effects of therapy on …