[HTML][HTML] Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease
MF Colavitta, FJ Barrantes - Pharmaceutics, 2023 - mdpi.com
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
[HTML][HTML] Alzheimer's disease: challenges and a therapeutic opportunity to treat it with a neurotrophic compound
N Baazaoui, K Iqbal - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious
onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are …
onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are …
The development of peptide-and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies
Introduction Tauopathies represent clinicopathological entities with increased and abnormal
glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense …
glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense …
[HTML][HTML] New insights into the therapeutic approaches for the treatment of tauopathies
Tauopathies are a group of neurological disorders, including Alzheimer's disease and
frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits …
frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits …
[HTML][HTML] Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse …
MW McNerney, EP Kraybill, S Narayanan… - Experimental …, 2023 - Elsevier
Alzheimer's disease is associated with a loss of plasticity and cognitive functioning. Previous
research has shown that repetitive transcranial magnetic stimulation (rTMS) boosts cortical …
research has shown that repetitive transcranial magnetic stimulation (rTMS) boosts cortical …
Increased Anxiety-like Behaviors in Adgra1−/− Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and …
XH Zhang, CL Shen, XY Wang, WF Xiong, X Shang… - Neuroscience, 2022 - Elsevier
Adhesion G protein-coupled receptor A1 (ADGRA1) belongs to the G protein-coupled
receptor (GPCR) family, and its physiological function remains largely unknown. We found …
receptor (GPCR) family, and its physiological function remains largely unknown. We found …
Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a …
SE Mackey-Alfonso, MJ Butler, AM Taylor… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative disease characterized by profound
memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers …
memory impairments, synaptic loss, neuroinflammation, and hallmark pathological markers …
Cellular and molecular mechanisms underly the combined treatment of fasudil and bone marrow derived-neuronal stem cells in a Parkinson's disease mouse model
Bone marrow-derived neural stem cells (BM-NSCs) have shed light on novel therapeutic
approaches for PD with the potential to halt or even reverse disease progression. Various …
approaches for PD with the potential to halt or even reverse disease progression. Various …
The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3× Tg-AD) mouse model strain
S Tian, T Ye, X Cheng - Experimental Neurology, 2023 - Elsevier
As a classic animal model of Alzheimer's disease (AD), the 3× Tg-AD mouse not only
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease
M Wei, T Wu, N Chen - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting
towards an aging population, AD has emerged as a prominent public health concern. The …
towards an aging population, AD has emerged as a prominent public health concern. The …