Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Half of all human cancers lose p53 function by missense mutations, with an unknown
fraction of these containing p53 in a self-aggregated amyloid-like state. Here we show that a …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

Protein-and RNA-containing foci and aggregates are a hallmark of many age-and mutation-
related neurodegenerative diseases. This article focuses on the role the nucleolus has as a …