Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …

Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

Cancer patients treated with antiangiogenic multitargeted receptor tyrosine kinase (RTK)
inhibitors show increased levels of plasma VEGF and placental growth factor and decreased …

The family of matricellular proteins comprises molecules with disparate biology. The main
characteristic of matricellular proteins is to be expressed during tissue renewal and repair in …

Angiogenesis is the hallmark of cancer, and development of aggressiveness of primary
tumor depends on de novo angiogenesis. Here, using multiple in vitro and in vivo models …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in some
areas of the world. In most cases, HCC is diagnosed at a late stage. Therefore, the …

Hypoxia is a salient feature of most solid tumors, and hypoxic adaptation of cancer cells has
crucial implications in propagation of malignant clonal cell population. Osteopontin (OPN) …

Osteopontin (OPN) is a highly modified integrin-binding extracellular matrix
glycophosphoprotein produced by cells of the immune system, epithelial tissue, smooth …

Introduction: Cancer is a complex pathological disorder, established as a result of
accumulation of genetic and epigenetic changes, which lead to adverse alterations in the …

Deregulation of signal transducer and activator of transcription (STAT)-3 signaling plays
crucial role in oncogenesis of various cancers. However, the molecular mechanism by which …