Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

D Sheehan, G Meade, VM Foley… - Biochemical journal, 2001 - portlandpress.com
The glutathione transferases (GSTs; also known as glutathione S-transferases) are major
phase II detoxification enzymes found mainly in the cytosol. In addition to their role in …

Glutathione transferases, regulators of cellular metabolism and physiology

PG Board, D Menon - Biochimica et biophysica acta (bba)-general subjects, 2013 - Elsevier
BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Glutathione S-transferase polymorphisms and their biological consequences

JD Hayes, RC Strange - Pharmacology, 2000 - karger.com
Two supergene families encode proteins with glutathione S-transferase (GST) activity: the
family of soluble enzymes comprises at least 16 genes; the separate family of microsomal …

Epidemiology of colorectal cancer

J Little, L Sharp - Colorectal Cancer, 2006 - taylorfrancis.com
In the United States in the period 1973–1997, the incidence and mortality due to large bowel
cancer was higher in blacks than in other ethnic groups. The incidence in blacks in the …

Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health

R Verkerk, M Schreiner, A Krumbein… - Molecular nutrition & …, 2009 - Wiley Online Library
Glucosinolates (GLSs) are found in Brassica vegetables. Examples of these sources include
cabbage, Brussels sprouts, broccoli, cauliflower and various root vegetables (eg radish and …

Meat as a component of a healthy diet–are there any risks or benefits if meat is avoided in the diet?

HK Biesalski - Meat science, 2005 - Elsevier
Meat is frequently associated with a “negative” health image due to its “high” fat content and
in the case of red meat is seen as a cancer-promoting food. Therefore, a low meat intake …

Glucosinolates, isothiocyanates and human health

M Traka, R Mithen - Phytochemistry reviews, 2009 - Springer
Concurrent with the increase in our knowledge of the genetic and environmental factors that
lead to glucosinolate accumulation in plants, and the role of these compounds and their …

A critical review of the bioavailability of glucosinolates and related compounds

B Holst, G Williamson - Natural product reports, 2004 - pubs.rsc.org
Covering: until June 2003 Glucosinolates (GLSs) are relatively inert (Z)-N-
hydroximinosulfate esters, possessing a sulfur-linked β-D-glucopyranose moiety and a …

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

SM Tortorella, SG Royce, PV Licciardi… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

Dietary constituents of broccoli and other cruciferous vegetables: implications for prevention and therapy of cancer

I Herr, MW Büchler - Cancer treatment reviews, 2010 - Elsevier
Over the past several decades, research on the action of bioactive constituents of plants has
focused predominantly on their cancer-preventive properties. Today it can be explained why …