Air− liquid Interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions
D Baldassi, B Gabold, OM Merkel - Advanced nanobiomed …, 2021 - Wiley Online Library
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
Transcytosis: crossing cellular barriers
PL Tuma, AL Hubbard - Physiological reviews, 2003 - journals.physiology.org
Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
There is an urgent need for antivirals to treat the newly emerged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …
Neutrophil recruitment by human IL-17 via CXC chemokine release in the airways
M Laan, ZH Cui, H Hoshino, J Lötvall… - The Journal of …, 1999 - journals.aai.org
IL-17 is a recently discovered cytokine that can be released from activated human CD4+ T
lymphocytes. This study assessed the proinflammatory effects of human (h) IL-17 in the …
lymphocytes. This study assessed the proinflammatory effects of human (h) IL-17 in the …
Airway gland structure and function
JH Widdicombe, JJ Wine - Physiological reviews, 2015 - journals.physiology.org
Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
CFTR, mucins, and mucus obstruction in cystic fibrosis
SM Kreda, CW Davis, MC Rose - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …
Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier
CI Grainger, LL Greenwell, DJ Lockley, GP Martin… - Pharmaceutical …, 2006 - Springer
Purpose The aim of this study was to compare the effect of liquid-covered culture (LCC) and
air-interfaced culture (AIC) on Calu-3 cell layer morphology and permeability, thus …
air-interfaced culture (AIC) on Calu-3 cell layer morphology and permeability, thus …
[HTML][HTML] Effects of Size and Surface Charge of Polymeric Nanoparticles on in Vitro and in Vivo Applications
Biodegradable polymeric materials are the most common carriers for use in drug delivery
systems. With this trend, newer drug delivery systems using targeted and controlled release …
systems. With this trend, newer drug delivery systems using targeted and controlled release …
Role of CFTR in airway disease
JM Pilewski, RA Frizzell - Physiological reviews, 1999 - journals.physiology.org
Pilewski, Joseph M., and Raymond A. Frizzell. Role of CFTR in Airway Disease. Physiol.
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …