Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference …

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has
rekindled an interest in earlier studies showing that transcription factors can directly convert …

In the three decades since pluripotent mouse embryonic stem (ES) cells were first described,
they have been derived and maintained by using various empirical combinations of feeder …

Pathogens have to balance transmission with persistence. For Plasmodium falciparum, the
most widespread and virulent malaria parasite, persistence within its human host requires …

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and
developing germ cells,. Deletion of Nanog causes early embryonic lethality, whereas …

There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using …

The reprogramming factors that induce pluripotency have been identified primarily from
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that …

Lineage specification of multipotent progenitor cells is governed by a balance of lineage-
affiliated transcription factors, such as GATA1 and PU. 1, which regulate the choice between …

Here we present Tellurium, a Python-based environment for model building, simulation, and
analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium …

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex
processes requiring the coordinated dynamic expression of hundreds of genes and proteins …