The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Anti-angiogenesis effect of a prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate
(Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment …

The monoamine neurotransmitter, 5-Hydroxytryptamine or serotonin, is derived from
tryptophan and synthesized both centrally and systemically. Fourteen structurally and …

Abstract The serotonin (5-HT) 6 receptor is a Gs-coupled receptor exclusively expressed in
the central nervous system. Highest receptor densities are found in brain regions implicated …

5-HT6 receptor (5-HT6R) is a G protein-coupled receptor that has recently emerged as a
new regulator of neural development. In addition to the canonical Gs adenylyl cyclase …

Epidemiological observations have shown that schizophrenia patients after long-term drug
treatment exhibited reduced tumor incidences. The potential anticancer effects of …

This study investigates the effects of environmentally-relevant concentrations of fluoxetine
(FLX, commercial name: Prozac) on wound healing. Pollution of water systems with …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory decline. It has been suggested that 5-hydroxytryptamine receptor 6 (5-HT6R) might …

High serotonin levels during pregnancy affect central nervous system development. Whether
a commonly used antidepressant such as fluoxetine (a selective serotonin reuptake …