Role of human milk bioactives on infants' gut and immune health
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …
life to promote optimal health outcomes during early life and beyond. Human milk contains a …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Role of salivary biomarkers in oral cancer detection
Oral cancers are the sixth most frequent cancer with a high mortality rate. Oral squamous
cell carcinoma accounts for more than 90% of all oral cancers. Standard methods used to …
cell carcinoma accounts for more than 90% of all oral cancers. Standard methods used to …
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges
Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency
virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 …
virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 …
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
H Mouquet, L Scharf, Z Euler, Y Liu… - Proceedings of the …, 2012 - National Acad Sciences
Broadly neutralizing HIV antibodies (bNAbs) can recognize carbohydrate-dependent
epitopes on gp120. In contrast to previously characterized glycan-dependent bNAbs that …
epitopes on gp120. In contrast to previously characterized glycan-dependent bNAbs that …
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
TC Chou - Pharmacological reviews, 2006 - ASPET
The median-effect equation derived from the mass-action law principle at equilibrium-steady
state via mathematical induction and deduction for different reaction sequences and …
state via mathematical induction and deduction for different reaction sequences and …
Antibodies in HIV-1 vaccine development and therapy
F Klein, H Mouquet, P Dosenovic, JF Scheid, L Scharf… - Science, 2013 - science.org
Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope
for a protective immunization. Renewed optimism in this area of research comes in part from …
for a protective immunization. Renewed optimism in this area of research comes in part from …
HIV‐1 neutralizing antibodies: understanding nature's pathways
JR Mascola, BF Haynes - Immunological reviews, 2013 - Wiley Online Library
The development of an effective vaccine has been hindered by the enormous diversity of
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
Broadly neutralizing antiviral antibodies
D Corti, A Lanzavecchia - Annual review of immunology, 2013 - annualreviews.org
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …
immune response. The widely held view has been that the great variability of viral …
Regulatory approval and a first‐in‐human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
JKC Ma, J Drossard, D Lewis, F Altmann… - Plant biotechnology …, 2015 - Wiley Online Library
Although plant biotechnology has been widely investigated for the production of clinical‐
grade monoclonal antibodies, no antibody products derived from transgenic plants have yet …
grade monoclonal antibodies, no antibody products derived from transgenic plants have yet …