Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …

Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …

Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …

Non-coding regions amplified beyond oncogene borders have largely been ignored. Using
a computational approach, we find signatures of significant co-amplification of non-coding …

Growth factor receptors rank among the most important oncogenic pathways, but
pharmacologic inhibitors often demonstrate limited benefit as monotherapy. Here, we show …

Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …

Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor
population and the tumor-immune microenvironment (TIME), prominently containing tumor …

Glioblastoma is the most lethal primary brain tumor with glioblastoma stem cells (GSCs) atop
a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive …