Recent advances in genetics and nucleic acid chemistry have created fundamentally new
tools, both for practical applications in therapy and diagnostics and for fundamental genome …

Lipophilic oligonucleotide conjugates represent a powerful tool for nucleic acid cellular
delivery, and many methods for their synthesis have been developed over the past few …

New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl) sulfonyl]
phosphoramidate or (hexadecylsulfonyl) phosphoramidate groups at internucleotidic …

Phosphoryl guanidine oligonucleotides (PGOs) are promising tools for biological research
and development of biosensors and therapeutics. We performed structural and hybridization …

The conjugation of lipophilic groups to oligonucleotides is a promising approach for
improving nucleic acid-based therapeutics' intracellular delivery. Lipid oligonucleotide …

Serum albumin is currently in the focus of biomedical research as a promising platform for
the creation of multicomponent self-assembling systems due to the presence of several sites …

It is known that epoxide-bearing compounds display pronounced pharmacological activities,
and the epoxidation of natural metabolites can be a promising strategy to improve their …

Lipophilic oligonucleotide derivatives are a potent approach to the intracellular delivery of
nucleic acids. The binding of these derivatives to serum albumin is a determinant of their fate …

Numerous types of oligonucleotide modifications have been developed since automated
synthesis of DNA/RNA became a common instrument in the creation of synthetic …

In this work, representatives of the class of triazinylamidophosphate oligonucleotide
derivatives were obtained for the first time. A scheme for the introduction of a modified unit …