Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …

Although it is generally believed that genetic and developmental factors play critical roles in
pathogenesis of schizophrenia, however, the precise etiological mechanism of …

The re-emergence (ie 'breakthrough') of depressive symptoms despite maintenance
treatment of depression with antidepressant drugs is a complex clinical phenomenon …

Cardiovascular morbidity and mortality are important problems among patients with
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …

The watershed-hypothesis of schizophrenia asserts that over 200 different mutations
dysregulate distinct pathways that converge on an unspecified common mechanism (s) that …

Treatment resistant schizophrenia (TRS) is characterized by a lack of, or suboptimal
response to, antipsychotic agents. The biological underpinnings of this clinical condition are …

Background: Copy number variation on chromosome 15q11. 2 (BP1-BP2) causes a deletion
of CYFIP1, NIPA1, NIPA2 and TUBGCP5. Furthermore, it also affects brain structure and …

Schizophrenia is a severe and debilitating psychiatric disorder of unknown etiology, and its
diagnosis is essentially based on clinical symptoms. Despite growing evidence on the …

The pathogenesis of schizophrenia in patients with metabolic abnormalities remains
unclear. Our previous study demonstrated that isolation rearing (IR) induced longitudinal …