BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …

Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Calcium carries messages to virtually all important functions of cells. Although it was already
active in unicellular organisms, its role became universally important after the transition to …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …