Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS

TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

U Neniskyte, CT Gross - Nature Reviews Neuroscience, 2017 - nature.com
The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …

Sculpting neural circuits by axon and dendrite pruning

MM Riccomagno, AL Kolodkin - Annual review of cell and …, 2015 - annualreviews.org
The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

[HTML][HTML] Synapse elimination in the developing cerebellum

K Hashimoto, M Kano - Cellular and molecular life sciences, 2013 - Springer
Neural circuits in neonatal animals contain numerous redundant synapses that are
functionally immature. During the postnatal period, unnecessary synapses are eliminated …

Climbing fiber synapse elimination in cerebellar Purkinje cells

M Watanabe, M Kano - European Journal of Neuroscience, 2011 - Wiley Online Library
Abstract Innervation of Purkinje cells (PCs) by multiple climbing fibers (CFs) is refined into
mono‐innervation during the first three postnatal weeks of rodents' lives. In this review …

Multiple phases of climbing fiber synapse elimination in the developing cerebellum

M Kano, T Watanabe, N Uesaka, M Watanabe - The cerebellum, 2018 - Springer
Functional neural circuits in the mature animals are shaped during postnatal development
by elimination of unnecessary synapses and strengthening of necessary ones among …

H2-Kb and H2-Db regulate cerebellar long-term depression and limit motor learning

MJ McConnell, YH Huang… - Proceedings of the …, 2009 - National Acad Sciences
There are more than 50 class I MHC (MHCI) molecules in the mouse genome, some of
which are now known to be expressed in neurons; however, the role of classical MHCI …

[HTML][HTML] Developmental synapse remodeling in the cerebellum and visual thalamus

M Kano, T Watanabe - F1000Research, 2019 - ncbi.nlm.nih.gov
Functional neural circuits of mature animals are shaped during postnatal development by
eliminating early-formed redundant synapses and strengthening of necessary connections …

[HTML][HTML] Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation

M Kaneko, K Yamaguchi, M Eiraku, M Sato, N Takata… - PloS one, 2011 - journals.plos.org
Dendrite arborization patterns are critical determinants of neuronal connectivity and
integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive …

Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival

F Biamonte, G Assenza, R Marino, M D'Amelio… - Neurobiology of …, 2009 - Elsevier
We determined total Purkinje cell (PC) numbers in cerebella of wild-type (+/+) and
heterozygous (rl/+) reeler mice of either sex during early postnatal development; in parallel …