Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
U Neniskyte, CT Gross - Nature Reviews Neuroscience, 2017 - nature.com
The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …
neuronal synapses. However, the same period is also associated with a peak in synapse …
Sculpting neural circuits by axon and dendrite pruning
MM Riccomagno, AL Kolodkin - Annual review of cell and …, 2015 - annualreviews.org
The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …
regressive events. Regressive events encompass a variety of inhibitory developmental …
[HTML][HTML] Synapse elimination in the developing cerebellum
K Hashimoto, M Kano - Cellular and molecular life sciences, 2013 - Springer
Neural circuits in neonatal animals contain numerous redundant synapses that are
functionally immature. During the postnatal period, unnecessary synapses are eliminated …
functionally immature. During the postnatal period, unnecessary synapses are eliminated …
Climbing fiber synapse elimination in cerebellar Purkinje cells
M Watanabe, M Kano - European Journal of Neuroscience, 2011 - Wiley Online Library
Abstract Innervation of Purkinje cells (PCs) by multiple climbing fibers (CFs) is refined into
mono‐innervation during the first three postnatal weeks of rodents' lives. In this review …
mono‐innervation during the first three postnatal weeks of rodents' lives. In this review …
Multiple phases of climbing fiber synapse elimination in the developing cerebellum
M Kano, T Watanabe, N Uesaka, M Watanabe - The cerebellum, 2018 - Springer
Functional neural circuits in the mature animals are shaped during postnatal development
by elimination of unnecessary synapses and strengthening of necessary ones among …
by elimination of unnecessary synapses and strengthening of necessary ones among …
H2-Kb and H2-Db regulate cerebellar long-term depression and limit motor learning
MJ McConnell, YH Huang… - Proceedings of the …, 2009 - National Acad Sciences
There are more than 50 class I MHC (MHCI) molecules in the mouse genome, some of
which are now known to be expressed in neurons; however, the role of classical MHCI …
which are now known to be expressed in neurons; however, the role of classical MHCI …
[HTML][HTML] Developmental synapse remodeling in the cerebellum and visual thalamus
M Kano, T Watanabe - F1000Research, 2019 - ncbi.nlm.nih.gov
Functional neural circuits of mature animals are shaped during postnatal development by
eliminating early-formed redundant synapses and strengthening of necessary connections …
eliminating early-formed redundant synapses and strengthening of necessary connections …
[HTML][HTML] Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation
Dendrite arborization patterns are critical determinants of neuronal connectivity and
integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive …
integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive …
Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival
F Biamonte, G Assenza, R Marino, M D'Amelio… - Neurobiology of …, 2009 - Elsevier
We determined total Purkinje cell (PC) numbers in cerebella of wild-type (+/+) and
heterozygous (rl/+) reeler mice of either sex during early postnatal development; in parallel …
heterozygous (rl/+) reeler mice of either sex during early postnatal development; in parallel …