This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

Bones provide mechanical and protective function, while also serving as housing for marrow
and a site for regulation of calcium ion homeostasis. The properties of bones do not remain …

Ontogenetic growth processes in human long bones are key elements, determining the
variability of adult bone structure. This study seeks to identify and describe the interaction …

Much is known about skeletal adaptation in relation to the mechanical functions that bones
serve. This includes how bone adapts to mechanical loading during an individual's lifetime …

This study uses synchrotron radiation‐based micro‐computed tomography (CT) scans to
reconstruct three‐dimensional networks of Haversian systems in human cortical bone in …

This review aims to provide a summary of current concepts of ageing in relation to the
musculoskeletal system, highlighting recent advances in the understanding of the …

The whole bone geometry, microstructure, and mechanical properties of mature human
bone are widely reported; however, immature bone (0–18 years) has not been similarly …

Cellular aging is associated with dysfunction of numerous tissues affecting multiple organ
systems. A striking example of this is related to age-related bone loss, or osteoporosis …

Objectives The femur is a major weight‐bearing bone that is variably loaded throughout
growth as children transition through locomotory states prior to the attainment of a mature …

Patterns of bone development in mammals are best known from terrestrial and cursorial
groups, but there is a considerable gap in our understanding of how specializations for life …