Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …

The molecular processes that contribute to degenerative diseases are not well understood.
Recent observations suggest that some degenerative diseases are promoted by the …

Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

MicroRNAs (miRNAs) are a conserved class of approximately 22 nucleotide (nt) short
noncoding RNAs that normally silence gene expression via translational repression and/or …

Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …

This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Competing models exist in the literature for the relationship between mutant Huntingtin exon
1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering …