Osteosarcoma (OS), chondrosarcoma, and chordoma are characterized by multiple
challenges to the investigator, clinician, and patient. One consequence of their rarity among …

This document is an update of the British Sarcoma Group guidelines (2016) and provides a
reference standard for the clinical care of UK patients with primary malignant bone tumours …

Highlights•This Clinical Practice Guideline provides key recommendations on the
management of bone sarcomas.•Recommendations have been agreed following a …

Primary bone tumours are rare, accounting for< 0.2% of malignant neoplasms registered in
the EUROCARE (European Cancer Registry based study on survival and care of cancer …

Chordoma is a rare tumor that occurs along the axial spine in pediatrics and adults, with an
incidence of approximately 350 cases per year in the United States. While typically …

Skull base chordomas account for less than 0.2% and chondrosarcomas for less than 0.15%
of all intracranial tumors. Although their clinical and imaging presentations are similar, they …

Identifying the spectrum of genes required for cancer cell survival can reveal essential
cancer circuitry and therapeutic targets, but such a map remains incomplete for many cancer …

Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-
exome and genome sequencing within a precision oncology program, that advanced …

Background No standard treatment exists for advanced chordoma. Apatinib has been found
to have promising efficacy and manageable adverse effects for the treatment of solid …

Simple Summary Skull-base chordomas (SBC) are rare tumours with unfavourable
outcomes, even when undergoing advanced treatments such as carbon-ion radiotherapy …