The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

All proteins in mammalian cells are continually being degraded and replaced. In the cytosol,
nucleus, and organelles, individual proteins are degraded at widely differing rates; some …

Cachexia is among the most debilitating and life‐threatening aspects of cancer. Associated
with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of …

About half of all cancer patients show a syndrome of cachexia, characterized by loss of
adipose tissue and skeletal muscle mass. Such patients have a decreased survival time …

The importance of β-adrenergic signaling in the heart has been well documented, but it is
only more recently that we have begun to understand the importance of this signaling …

Muscle protein wasting in cancer cachexia is a critical problem. The underlying mechanisms
are still unclear, although the ubiquitin-proteasome system has been involved in the …

Cachexia represents the clinical consequence of a chronic, systemic inflammatory response,
and its manifestations differ considerably from those of starvation. Although cachexia is …

Chronic renal failure (CRF) is associated with negative nitrogen balance and loss of lean
body mass. To identify specific proteolytic pathways activated by CRF, protein degradation …

Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …