The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

System xc− cystine/glutamate antiporter, composed of a light-chain subunit (xCT, SLC7A11)
and a heavy-chain subunit (CD98hc, SLC3A2), is mainly responsible for the cellular uptake …

Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by
excessive lipid peroxide accumulation. This novel cell death modality has been implicated in …

Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …

Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4
inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but …

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …