Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient
composition or energy restriction. To elucidate mechanisms underpinning the effects of short …

In association with sleep–wake and fasting–feeding cycles, organisms experience dramatic
oscillations in energetic demands and nutrient supply. It is therefore not surprising that …

Metabolomics is a promising approach for the identification of chemical compounds that
serve for early detection, diagnosis, prediction of therapeutic response and prognosis of …

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

Nutrition research is struggling to demonstrate beneficial health effects, since nutritional
effects are often subtle and long term. Health has been redefined as the ability of our body to …

The combination of multiple omics approaches has emerged as an innovative holistic scope
to provide a more comprehensive view of the molecular and physiological events underlying …

Across the globe, there has been a marked increase in longevity, but significant inequalities
remain. These are exacerbated by inadequate access to proper nutrition and health care …

Background A key feature of metabolic health is the ability to adapt upon dietary
perturbations. Recently, it was shown that metabolic challenge tests in combination with the …