Synaptopathology involved in autism spectrum disorder

S Guang, N Pang, X Deng, L Yang, F He… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Mechanisms that modulate and diversify BDNF functions: implications for hippocampal synaptic plasticity

AP De Vincenti, AS Ríos, G Paratcha… - Frontiers in cellular …, 2019 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on
neuronal morphology and synaptic plasticity that underlie hippocampal circuit development …

Neuropsychopathology of autism spectrum disorder: complex interplay of genetic, epigenetic, and environmental factors

R Bhandari, JK Paliwal, A Kuhad - … food intervention and therapy for autism …, 2020 - Springer
Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …

Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent …

S Abuaish, NM Al-Otaibi, TS Abujamel, SA Alzahrani… - Brain Sciences, 2021 - mdpi.com
Autism is associated with gastrointestinal dysfunction and gut microbiota dysbiosis,
including an overall increase in Clostridium. Modulation of the gut microbiota is suggested to …

Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice

A Mossa, J Pagano, L Ponzoni, A Tozzi, E Vezzoli… - Molecular …, 2021 - nature.com
Human mutations and haploinsufficiency of the SHANK family genes are associated with
autism spectrum disorders (ASD) and intellectual disability (ID). Complex phenotypes have …

Hippocampal deficits in neurodevelopmental disorders

Y Li, M Shen, ME Stockton, X Zhao - Neurobiology of learning and memory, 2019 - Elsevier
Neurodevelopmental disorders result from impaired development or maturation of the
central nervous system. Both genetic and environmental factors can contribute to the …

Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies

M Premoli, M Memo, SA Bonini - Neural Regeneration Research, 2021 - journals.lww.com
Mice use ultrasonic vocalizations (USVs) to communicate each other and to convey their
emotional state. USVs have been greatly characterized in specific life phases and contexts …

A placental mammal‐specific micro RNA cluster acts as a natural brake for sociability in mice

M Lackinger, AÖ Sungur, R Daswani, M Soutschek… - EMBO …, 2019 - embopress.org
Aberrant synaptic function is thought to underlie social deficits in neurodevelopmental
disorders such as autism and schizophrenia. Although micro RNA s have been shown to …

Increasing astrogenesis in the developing hippocampus induces autistic‐like behavior in mice via enhancing inhibitory synaptic transmission

J Chen, XL Ma, H Zhao, XY Wang, MX Xu, H Wang… - Glia, 2022 - Wiley Online Library
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder
characterized primarily by impaired social communication and rigid, repetitive, and …

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the …

A Pignataro, P Krashia, M De Introna, A Nobili… - Translational …, 2023 - nature.com
Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show
an autistic-like phenotype associated with hippocampal circuits dysfunctions which include …