Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood

MI Setyawati, CY Tay, D Docter, RH Stauber… - Chemical Society …, 2015 - pubs.rsc.org
While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

EMT in cervical cancer: its role in tumour progression and response to therapy

R Qureshi, H Arora, MA Rizvi - Cancer letters, 2015 - Elsevier
The prognosis of cervical patients significantly decreases as the cancer metastasizes to
other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important …

Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

H Yanagisawa, EC Davis, BC Starcher, T Ouchi… - Nature, 2002 - nature.com
Extracellular elastic fibres provide mechanical elasticity to tissues and contribute towards the
processes of organ remodelling by affecting cell–cell signalling,. The formation of elastic …

Fibulin-5/DANCE is essential for elastogenesis in vivo

T Nakamura, PR Lozano, Y Ikeda, Y Iwanaga, A Hinek… - Nature, 2002 - nature.com
The elastic fibre system has a principal role in the structure and function of various types of
organs that require elasticity, such as large arteries, lung and skin,. Although elastic fibres …

Fibulins: a versatile family of extracellular matrix proteins

R Timpl, T Sasaki, G Kostka, ML Chu - Nature reviews Molecular cell …, 2003 - nature.com
Fibulins are a newly recognized family of extracellular matrix proteins. The five known
members of the family share an elongated structure and many calcium-binding sites, owing …

Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface

GL Dale, P Friese, P Batar, SF Hamilton, GL Reed… - Nature, 2002 - nature.com
Activated platelets bind numerous adhesive and procoagulant proteins by receptor-
mediated processes. Although there is little evidence to suggest that these processes are …

Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

C Daly, V Wong, E Burova, Y Wei, S Zabski… - Genes & …, 2004 - genesdev.cshlp.org
Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of
vascular development, the molecular mechanisms underlying Ang-1 function are almost …

Extracellular matrix dynamics in vascular remodeling

Z Ma, C Mao, Y Jia, Y Fu… - American Journal of …, 2020 - journals.physiology.org
Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Fibulins: physiological and disease perspectives

WS Argraves, LM Greene, MA Cooley… - EMBO …, 2003 - embopress.org
The fibulins are a family of proteins that are associated with basement membranes and
elastic extracellular matrix fibres. This review summarizes findings from studies of animal …