Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Microfluidic technologies for cell deformability cytometry

H Chen, J Guo, F Bian, Y Zhao - Smart Medicine, 2022 - Wiley Online Library
Microfluidic detection methods for cell deformability cytometry have been regarded as
powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been …

Impedance‐Based Multimodal Electrical‐Mechanical Intrinsic Flow Cytometry

Y Feng, J Zhu, H Chai, W He, L Huang, W Wang - Small, 2023 - Wiley Online Library
Reflecting various physiological states and phenotypes of single cells, intrinsic biophysical
characteristics (eg, mechanical and electrical properties) are reliable and important, label …

Poly (ethylene oxide) concentration gradient-based microfluidic isolation of circulating tumor cells

Y Cheng, S Zhang, L Qin, J Zhao, H Song… - Analytical …, 2023 - ACS Publications
Circulating tumor cells (CTCs) have emerged as promising circulating biomarkers for non-
invasive cancer diagnosis and management. Isolation and detection of CTCs in clinical …

[HTML][HTML] Selectable encapsulated cell quantity in droplets via label-free electrical screening and impedance-activated sorting

J Zhong, M Liang, Q Tang, Y Ai - Materials Today Bio, 2023 - Elsevier
Single-cell encapsulation in droplets has become a powerful tool in immunotherapy,
medicine discovery, and single-cell analysis, thanks to its capability for cell confinement in …

Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes

J Zhong, M Liang, Y Ai - Lab on a Chip, 2021 - pubs.rsc.org
Submicron-precision particle characterization is crucial for counting, sizing and identifying a
variety of biological particles, such as bacteria and apoptotic bodies. Microfluidic impedance …

Inertial microfluidics for high-throughput cell analysis and detection: a review

Z Zhou, Y Chen, S Zhu, L Liu, Z Ni, N Xiang - Analyst, 2021 - pubs.rsc.org
Since it was first proposed in 2007, inertial microfluidics has been extensively studied in
terms of theory, design, fabrication, and application. In recent years, with the rapid …

Machine learning empowered multi-stress level electromechanical phenotyping for high-dimensional single cell analysis

M Liang, Q Tang, J Zhong, Y Ai - Biosensors and Bioelectronics, 2023 - Elsevier
Microfluidics provides a powerful platform for biological analysis by harnessing the ability to
precisely manipulate fluids and microparticles with integrated microsensors. Here, we …

Impedance‐enabled camera‐free intrinsic mechanical cytometry

Y Feng, H Chai, W He, F Liang, Z Cheng… - Small …, 2022 - Wiley Online Library
Mechanical properties of single cells are important label‐free biomarkers normally
measured by expensive and complex imaging systems. To unlock this limit and allow …

High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel

Z Zhou, C Ni, Z Zhu, Y Chen, Z Ni, N Xiang - Lab on a Chip, 2023 - pubs.rsc.org
Cell mechanical properties provide a label-free marker for indicating cell states and disease
processes. Although microfluidic deformability cytometry has demonstrated great potential …