A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …
medical imperative that in recent years motivates the talents of numerous investigators …
Techniques for the assessment of in vitro and in vivo antifungal combinations
AL Bidaud, P Schwarz, G Herbreteau, E Dannaoui - Journal of Fungi, 2021 - mdpi.com
Systemic fungal infections are associated with high mortality rates despite adequate
treatment. Moreover, acquired resistance to antifungals is increasing, which further …
treatment. Moreover, acquired resistance to antifungals is increasing, which further …
Synthesis and investigation of novel benzimidazole derivatives as antifungal agents
The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …
strains have resulted in an increase in demand for new antifungal agents. Various …
Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans
R Vazquez-Munoz, MJ Arellano-Jimenez… - BMC biomedical …, 2020 - Springer
Background Bismuth compounds are known for their activity against multiple
microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain …
microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain …
Alkylated piperazines and piperazine-azole hybrids as antifungal agents
N Thamban Chandrika, SK Shrestha… - Journal of Medicinal …, 2018 - ACS Publications
The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence
and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity …
and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity …
Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans
Y Gong, W Liu, X Huang, L Hao, Y Li… - Frontiers in microbiology, 2019 - frontiersin.org
Candida albicans is a common opportunistic fungal pathogen that may cause nosocomial
fungal infections. The resistance of Candida albicans to traditional antifungal drugs has …
fungal infections. The resistance of Candida albicans to traditional antifungal drugs has …
Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities
NT Chandrika, S Garneau-Tsodikova - Chemical Society Reviews, 2018 - pubs.rsc.org
A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …
A complex game of hide and seek: the search for new antifungals
Fungal infections directly affect millions of people each year. In addition to the invasive
fungal infections of humans, the plants and animals that comprise our primary food source …
fungal infections of humans, the plants and animals that comprise our primary food source …
Guiding drugs to target‐harboring organelles: Stretching drug‐delivery to a higher level of resolution
The ratio between the dose of drug required for optimal efficacy and the dose that causes
toxicity is referred to as the therapeutic window. This ratio can be increased by directing the …
toxicity is referred to as the therapeutic window. This ratio can be increased by directing the …
Combatting fungal infections: advances in antifungal polymeric nanomaterials
Fungal pathogens cause over 6.5 million life-threatening systemic infections annually, with
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …