Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Infection by pathogens is generally initiated by the specific recognition of host epithelia
surfaces and subsequent adhesion is essential for invasion. In their infection strategy …

Saturation transfer difference (STD) NMR has emerged as one of the most popular ligand-
based NMR techniques for the study of protein− ligand interactions. The success of this …

The spike protein N-terminal domains (NTDs) of bovine coronavirus (BCoV) and mouse
hepatitis coronavirus (MHV) recognize sugar and protein receptors, respectively, despite …

Diseases that result from infection are, in general, a consequence of specific interactions
between a pathogenic organism and the cells. The study of host-pathogen interactions has …

We used NMR spectroscopy, molecular modeling and infectivity competition assays to
investigate the key interactions between the spike protein (VP8*) from'sialidase …

A large number of viruses, including many human pathogens, bind cell-surface glycans
during the initial steps of infection. Viral glycan receptors such as glycosaminoglycans and …

Oligo-and polysaccharides are infamous for being extremely flexible molecules, populating
a series of well-defined rotational isomeric states under physiological conditions …

Viruses within a family often vary in their cellular tropism and pathogenicity. In many cases,
these variations are due to viruses switching their specificity from one cell surface receptor to …

Understanding the dynamics of protein–ligand interactions, which lie at the heart of host–
pathogen recognition, represents a crucial step to clarify the molecular determinants …