Pathogenicity and virulence of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection
Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in …
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …
[HTML][HTML] MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …
Mechanisms of TLR4-mediated autophagy and nitroxidative stress
K Zhang, Q Huang, S Deng, Y Yang, J Li… - Frontiers in Cellular and …, 2021 - frontiersin.org
Pathogenic infections have badly affected public health and the development of the
breeding industry. Billions of dollars are spent every year fighting against these pathogens …
breeding industry. Billions of dollars are spent every year fighting against these pathogens …
Mycobacterium tuberculosis PPE51 inhibits autophagy by suppressing toll-like receptor 2-dependent signaling
EJ Strong, J Wang, TW Ng, SA Porcelli, S Lee - MBio, 2022 - Am Soc Microbiol
Autophagy is an ubiquitous homeostatic pathway in mammalian cells and plays a significant
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …
Therapeutic potential of curcumin as an antimycobacterial agent
N Barua, AK Buragohain - Biomolecules, 2021 - mdpi.com
Curcumin is the principal curcuminoid obtained from the plant Curcuma longa and has been
extensively studied for its biological and chemical properties. Curcumin displays a vast …
extensively studied for its biological and chemical properties. Curcumin displays a vast …
Regulation of autophagy by SARS‐CoV‐2: The multifunctional contributions of ORF3a
Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) regulates autophagic flux
by blocking the fusion of autophagosomes with lysosomes, causing the accumulation of …
by blocking the fusion of autophagosomes with lysosomes, causing the accumulation of …
Tuberculosis and autoimmunity
IV Belyaeva, AN Kosova, AG Vasiliev - Pathophysiology, 2022 - mdpi.com
Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is
long-established that pathogenesis of many autoimmune diseases is mainly promoted by …
long-established that pathogenesis of many autoimmune diseases is mainly promoted by …